Health informatics (HI) recommendations on competencies and education underpin the design of curricula and courses, but they cannot inform educators on how the content can be customized for local needs and requirements. The International Competency Synthesis Project (ICSP) and the EU*US eHealth Work Project funded by the European Union were executed to empirically describe and validate the TIGER (Technology Informatics Guiding Education Reform) Initiative framework of HI competencies for a broad range of health professionals and their inter-professional collaboration [1, 2]. The framework consists of a grid of competency areas and professional roles with each cell informing about the relevance of a competency by role and practical examples from local case studies. Empirical input about the framework was provided by experts from 21 countries (Framework 1.0) and from 51 countries (Framework 2.0). The surveys were designed using evidence-based competencies extracted from the international literature and incorporating recommendations from national and international professional associations. The framework is the first of its kind to reconcile the needs for both a global overview and for local hands-on experience in teaching and learning health informatics.