Clozapine-induced myocarditis is a potentially fatal but often under-diagnosed complication of clozapine therapy. The Centre for Addiction and Mental Health (CAMH) in Toronto implemented and enforced myocarditis monitoring and prevention protocols for all patients initiated on clozapine to reduce the risk of serious complications. In previous state, physicians had to select twenty-three individual orders and two referrals; implementation of order sets (on simpler non-titration pathway) has simplified this process into two order sets. In addition, physician leadership is satisfied due to increased standardization of care and availability of data offered through the order sets. This presentation will cover the guiding principles of this initiative as well as the approval and review processes, key findings, and implications for other health care organizations.