Billions of dollars could be saved if healthcare data were truly interoperable. This presentation describes the technical infrastructure and operational processes developed to capture high-quality, semantically interoperable clinical data at the point of care. It is integrated into our healthcare processes, the data is used in registry reporting, and the near real-time analytics enabled by the data. We adapted off-the-shelf commercial software with targeted data capture instruments and enabled by a rules engine in order to provide real-time, clinical feedback. This is to replace the traditional method of information abstraction for registry reporting. What we accomplished via structured reporting, along with the accompanying challenges and mitigation strategies, will be described. A summary of major categorical benefits realized by the organization will be shared, including financial savings, return on investment (ROI), impact on clinical quality and outcomes, and key lessons for your healthcare enterprise.