Social determinants of health (SDoH) have been linked to patients’ clinical profiles. Addressing SDoH is vital for improving population health and reducing health disparities. ICD codes for SDoH exist, but research is lacking in how patients with SDoH codes differ from the general patient population in clinical diagnoses and outcomes. This session will fill that gap by analyzing longitudinal data from the nation’s largest repository of private healthcare claim records. The session will identify the most common SDoH and the most common diagnoses that co-occur with those SDoH, and compare those to the most common diagnoses in the population of all patients. Geographic and demographic factors will be included. The session will also evaluate outcomes of clinical conditions in patients with SDoH against outcomes in all patients with the corresponding condition. The results will have implications for public policy and clinical practice.