The prevalence of mental disorders, such as depression and anxiety, is increasing dramatically worldwide, and current models of mental healthcare are not able to cover this huge demand. Innovation in terms of service provision and treatment alternatives is needed, and is where digital health solutions can play a key role. This proposal will report on the results of a randomized controlled trial, aimed to test the effectiveness and cost-effectiveness of digital therapeutics for individuals with depression and anxiety when deployed within a stepped-care model of mental health care in the UK. A second goal is to explain how the outcomes from this trial are complementary to the implementation of digital therapeutics into US healthcare organizations. A case study with OSF healthcare in Illinois shows the effectiveness of digital mental health treatments, similar to those presented in the trial, and how these collaborations build potential for future work and improvement of health care at scale.