The cost of clinical trials has continued to grow, resulting in delays in bringing therapeutics to market. Also, the explosion of tech and IOT is revolutionizing care. These same technologies should be applied to research. The Apple Heart Study, an app-based, investigational device exemption study to identify atrial fibrillation using a smartwatch algorithm, enrolled 420,000 adults in less than 9 months. The study demonstrated innovative features, including the fully app-based design for enrollment and patient-reported outcomes, as well as the virtual nature of its design and execution which included telehealth visits. No physical “brick and mortar” visits were performed, which afforded the opportunity to massively scale. The session shares findings and pertinent examples from AHS for enabling virtual, telehealth focused clinical trials at scale and how academic medical centers and technology partners can effectively collaborate to build innovative digital models that promote collaborative research.