The Centers for Medicare and Medicaid Services (CMS) and the Michigan Department of Health and Human Services (MDHHS) selected the Greater Flint Health Coalition (GFHC), to implement a State Innovation Model (SIM) initiative. GFHC designed a clinical-community linkage model to meet the population health needs of 41,000 Medicaid qualified adults. The collaborative effort engaged local physician organizations, Medicaid health plans, hospitals, specialty hubs, and a collective of community and social service organizations. Great Lakes Health Connect (GLHC), the leading HIE in Michigan, became a partner in this effort to provide custom reporting on targeted populations, enhance communications, and streamline processing among the various collaborating entities. This presentation will provide an overview of the process involved in designing and deploying the Genesee Community Health Innovation Region as part of Michigan’s State Innovation Model Initiative. Specific opportunities, challenges, and outcomes to date will be discussed.