Applying scientific evidence into practice easily, quickly, accurately, and consistently is critical for high quality patient care. The maturation of standards, such as Fast Healthcare Interoperability Resources (FHIR), now require widespread adoption to help impact patient care. With broad stakeholder input from guideline developers, CDS implementers and users, evaluators, etc., a standards-based standardized approach is now available to serve as a framework for shareable, interoperable, computable guidelines. An implementation guide (IG) on the Representation of Clinical Practice Guideline Recommendations in FHIR (“CPG-on-FHIR”), balloted through HL7, incorporates the necessary building blocks for developing and implementing computable guidelines internationally. Accompanying guidance on a proposed process for integrating the perspectives and activities of guideline developers, informaticians, implementers and users, evaluators, and communicators, from the beginning of the guideline development process is forthcoming. This session will review the international effort that led to this IG and provide a detailed overview of the IG components and how they can help move toward computable guidelines.