Thanks to recent actions from Congress and two key federal agencies, the healthcare industry may soon adopt new tools that have revolutionized the modern internet: application programming interfaces (APIs). These tools will help connect patients with their data, provide new clinical decision support tools to providers, and support interoperability. To assess whether these new rules will support the needs of clinicians and patients, The Pew Charitable Trusts led focus groups with patients around the country on how they want their data exchanged. In tandem, Pew conducted structured interviews with hospitals and electronic health record (EHR) developers on their current capabilities, and the challenges and benefits of using APIs to improve the availability and interoperability of healthcare data. This session will provide results and foster discussion on all three of these perspectives, which are critical in understanding current and future use of APIs to promote interoperability.