2016 HIMSS Davies Award winner North York General Hospital engaged physicians and other interprofessional groups of clinicians in a two-and-a-half year, carefully managed process to create a library of over 350 electronic order sets. Unique to this process was the way in which evidence was carefully integrated into all clinical content and workflows, and how front-line clinicians were involved at every step. The result was that NYGH clinicians fully embraced the new Computerized Physician Order Entry (CPOE) system and order sets as their own. Broad and deep adoption was evidenced by a dramatic increase in order set use, from 36 percent of medical patient volume (paper-based, pre-eCare) to over 97 percent (eCare CPOE). What’s more, clinician adherence to the evidence-based order sets has significantly lowered the probability of in-hospital death from pneumonia or exacerbation of chronic obstructive pulmonary disease (COPD).