Over the past few years, numerous disasters, crises and attacks have struck the United States. In 2017 alone, we have seen natural disasters such as Hurricanes Harvey, Irma and Maria devastating and displacing large regions; mass casualties like the Las Vegas shooting; public health crises, such as the opioid epidemic; and cyber threats, like WannaCry, compromising health systems, providers and medical devices globally. In incidents such as these, a health system’s capability to maintain operations and quickly bring together disparate information is critical to effective recovery efforts. This panel will explore the evolution of interoperability and the role health information exchange plays in preparedness and crisis response. Panelists will discuss the progress made since Hurricane Katrina in 2005, discuss real-world lessons learned and best practices, and consider how health information exchange can continue to serve the public good and remain an integral part of crisis management.